The purpose of this development research is to produce a guide to general Biology-based problem solving using 3D pageflip as teaching material used by students in general Biology practicum. This research is motivated by the lack of availability of general Biology practicum guides at IAIN Kerinci and exploring students' scientific work knowledge and skills. The model used in developing this practicum is ADDIE model which consists of 5 stages including analysis, design, development, implementation, and evaluation. The practicum guide was validated by media experts twice with the acquisition of a final percentage of 81% in the highly valid category and validation by material experts three times with a final percentage of 82% in the very valid category. In conclusion, the constructivism-based Genetics e-module is equipped with mind mapping using 3D pageflip that is suitable for use in tertiary institutions.